CMap Candidate Details

Structure:
CMap ID: C00486
Pert ID: BRD-A19195498
Compound Name: trimipramine
Targets: SLC6A2; SLC6A3; SLC6A4
MoA: Tricyclic antidepressant; Norepinephrine reputake inhibitor
SMILES: CC(CN(C)C)CN1c2ccccc2CCc2ccccc12
InchiKey: ZSCDBOWYZJWBIY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5390 BRD-A19195498 HA1E 10 uM 6 h 0.24 1.0 0.11 0.0 0.0 0.0
5504 BRD-A19195498 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6453 BRD-A19195498 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39390 BRD-A19195498 A549 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.43
39552 BRD-A19195498 ASC 10 uM 24 h 0.0 0.0 0.0 0.36 1.29 1.49
39882 BRD-A19195498 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.87
40684 BRD-A19195498 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40978 BRD-A19195498 NPC 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
41301 BRD-A19195498 SKB 10 uM 24 h -0.24 -0.98 0.13 0.25 0.88 0.18
96444 BRD-A19195498 A375 10 uM 24 h -0.16 -0.67 0.0 0.0 0.0 0.0
96512 BRD-A19195498 PC3 1.11 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.27
120928 BRD-A19195498 HEK293 10 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
120992 BRD-A19195498 HELA 10 uM 3 h -0.3 -1.23 0.63 0.33 1.16 0.9
121026 BRD-A19195498 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
121086 BRD-A19195498 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129177 BRD-A19195498 HT29 0.01 uM 24 h -0.23 -0.96 0.1 0.26 0.91 0.23
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).