CMap Candidate Details

Structure:
CMap ID: C04897
Pert ID: BRD-K07857022
Compound Name: alvimopan
Targets: OPRD1; OPRK1; OPRM1
MoA: Opioid receptor antagonist
SMILES: C[C@H]1CN(C[C@H](Cc2ccccc2)C(=O)NCC(O)=O)CC[C@@]1(C)c1cccc(O)c1
InchiKey: UPNUIXSCZBYVBB-JVFUWBCBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95472 BRD-K07857022 U2OS 10 uM 6 h 0.27 1.12 0.26 -0.26 -0.88 0.26
128125 BRD-K07857022 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128157 BRD-K07857022 A549 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128196 BRD-K07857022 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128250 BRD-K07857022 MCF10A 1.11 uM 24 h 0.22 0.91 0.04 0.23 0.81 0.08
128329 BRD-K07857022 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135834 BRD-K07857022 HA1E 0.01 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
135870 BRD-K07857022 HEK293 0.74 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
135924 BRD-K07857022 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136014 BRD-K07857022 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.19
136041 BRD-K07857022 MCF??7.00 0.03 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
136074 BRD-K07857022 PC3 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136104 BRD-K07857022 THP1 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136159 BRD-K07857022 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).