CMap Candidate Details

Structure:
CMap ID: C04898
Pert ID: BRD-K07859598
Compound Name: GW-5074
Targets: RAF1
MoA: RAF inhibitor; Leucine rich repeat kinase inhibitor
SMILES: Oc1c(Br)cc(cc1Br)C=C1/C(=O)Nc2ccc(I)cc12
InchiKey: LMXYVLFTZRPNRV-KMKOMSMNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
69 BRD-K07859598 BJAB 0.01 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
102 BRD-K07859598 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135 BRD-K07859598 K562 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
193 BRD-K07859598 KMS34 0.125 uM 24 h -0.33 -1.36 1.06 0.0 0.0 0.0
232 BRD-K07859598 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
272 BRD-K07859598 OCILY10 0.66 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
316 BRD-K07859598 OCILY19 10 uM 4 h -0.2 -0.84 0.0 0.0 0.0 0.0
353 BRD-K07859598 OCILY3 0.125 uM 4 h 0.0 0.0 0.0 -0.24 -0.81 0.13
390 BRD-K07859598 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
429 BRD-K07859598 THP1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
470 BRD-K07859598 TMD8 10 uM 4 h 0.0 0.0 0.0 -0.34 -1.13 0.98
5297 BRD-K07859598 HA1E 10 uM 24 h -0.28 -1.16 0.47 0.0 0.0 0.0
5573 BRD-K07859598 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6518 BRD-K07859598 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37868 BRD-K07859598 HEPG2 10 uM 6 h 0.27 1.12 0.26 0.0 0.0 0.0
38048 BRD-K07859598 HT29 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.78
38180 BRD-K07859598 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
38685 BRD-K07859598 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38908 BRD-K07859598 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91504 BRD-K07859598 BT20 10 uM 24 h 0.19 0.81 0.0 -0.22 -0.74 0.05
91596 BRD-K07859598 HS578T 10 uM 6 h 0.21 0.87 0.01 -0.41 -1.38 2.02
91617 BRD-K07859598 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91683 BRD-K07859598 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91766 BRD-K07859598 SKBR3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
94408 BRD-K07859598 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94507 BRD-K07859598 ASC 10 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
94537 BRD-K07859598 CD34 10 uM 24 h 0.26 1.09 0.22 0.0 0.0 0.0
94628 BRD-K07859598 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94680 BRD-K07859598 HELA 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94731 BRD-K07859598 HME1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94825 BRD-K07859598 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94877 BRD-K07859598 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95004 BRD-K07859598 NEU 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95049 BRD-K07859598 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95111 BRD-K07859598 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95150 BRD-K07859598 SHSY5Y 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95200 BRD-K07859598 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96109 BRD-K07859598 A549 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.57
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).