CMap Candidate Details

Structure:
CMap ID: C04905
Pert ID: BRD-K07881437
Compound Name: danusertib
Targets: FGFR1; NTRK1; RET; AURKA; AURKC; AURKB
MoA: Aurora kinase inhibitor; Growth factor receptor inhibitor
SMILES: CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1
InchiKey: XKFTZKGMDDZMJI-HSZRJFAPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30357 BRD-K07881437 ASC 10 uM 24 h 0.0 0.0 0.0 0.4 1.41 2.18
30961 BRD-K07881437 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31263 BRD-K07881437 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31574 BRD-K07881437 HT29 10 uM 6 h 0.0 0.0 0.0 0.26 0.91 0.23
31992 BRD-K07881437 MCF??7.00 10 uM 6 h -0.32 -1.34 0.98 -0.17 -0.58 0.0
32348 BRD-K07881437 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32734 BRD-K07881437 PC3 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.85
32940 BRD-K07881437 SKB 10 uM 24 h 0.28 1.16 0.36 0.0 0.0 0.0
33242 BRD-K07881437 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.59
95495 BRD-K07881437 A549 10 uM 24 h 0.21 0.87 0.01 0.31 1.08 0.66
95643 BRD-K07881437 U2OS 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121139 BRD-K07881437 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121209 BRD-K07881437 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121244 BRD-K07881437 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121337 BRD-K07881437 YAPC 10 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.08
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).