CMap Candidate Details

Structure:
CMap ID: C00491
Pert ID: BRD-A19500257
Compound Name: geldanamycin
Targets: HSP90AA1
MoA: HSP inhibitor
SMILES: COC1CC(C)CC2=C(OC)C(=O)C=C(NC(=O)C(C)=CC=CC(OC)C(OC(N)=O)C(C)=CC(C)C1O)C2=O
InchiKey: QTQAWLPCGQOSGP-VDYWNIEOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
997 BRD-A19500257 CD34 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1027 BRD-A19500257 HL60 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
1121 BRD-A19500257 U937 10 uM 6 h 0.0 0.0 0.0 0.23 0.81 0.09
5713 BRD-A19500257 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9276 BRD-A19500257 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9579 BRD-A19500257 H1299 10 uM 6 h 0.0 0.0 0.0 -0.39 -1.31 1.71
10388 BRD-A19500257 HCT116 10 uM 6 h -0.25 -1.04 0.21 0.33 1.17 0.97
11327 BRD-A19500257 NCIH2073 10 uM 6 h -0.28 -1.15 0.44 0.37 1.31 1.59
11645 BRD-A19500257 NCIH508 10 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.29
11897 BRD-A19500257 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12195 BRD-A19500257 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.35 1.25 1.29
12655 BRD-A19500257 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12918 BRD-A19500257 THP1 10 uM 6 h 0.0 0.0 0.0 0.36 1.26 1.29
20523 BRD-A19500257 HT29 10 uM 6 h 0.0 0.0 0.0 0.33 1.15 0.9
26195 BRD-A19500257 ASC 10 uM 24 h 0.0 0.0 0.0 0.39 1.37 2.11
38828 BRD-A19500257 SKB 10 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
52946 BRD-A19500257 HEPG2 4 uM 3 h 0.25 1.05 0.16 0.0 0.0 0.0
53546 BRD-A19500257 HUH7 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.7 0.03
53628 BRD-A19500257 PHH 10 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
63038 BRD-A19500257 PC3 10 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
67417 BRD-A19500257 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
72356 BRD-A19500257 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
73998 BRD-A19500257 MCF??7.00 10 uM 24 h -0.15 -0.61 0.0 -0.24 -0.79 0.11
80758 BRD-A19500257 NPC 1.11 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.65
81973 BRD-A19500257 NEU 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
88864 BRD-A19500257 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90509 BRD-A19500257 HA1E 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.86
92031 BRD-A19500257 BT20 10 uM 24 h -0.2 -0.85 0.01 0.24 0.85 0.14
92170 BRD-A19500257 HS578T 3.33 uM 3 h 0.0 0.0 0.0 -0.31 -1.04 0.68
92243 BRD-A19500257 MCF10A 0.04 uM 3 h -0.27 -1.13 0.4 0.31 1.09 0.67
92322 BRD-A19500257 MDAMB231 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92547 BRD-A19500257 HME1 10 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.28
92685 BRD-A19500257 LNCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92840 BRD-A19500257 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97425 BRD-A19500257 NKDBA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99720 BRD-A19500257 U2OS 20 uM 6 h -0.24 -1.0 0.15 -0.27 -0.9 0.28
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).