CMap Candidate Details

Structure:
CMap ID: C04925
Pert ID: BRD-K07954936
Compound Name: 2-iminobiotin
Targets: NOS1; NOS2
MoA: Nitric oxide synthase inhibitor
SMILES: OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=N)N[C@H]12
InchiKey: WWVANQJRLPIHNS-ZKWXMUAHSA-N
Compound Aliases: 2-IMINOBIOTIN

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
121141 BRD-K07954936 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121176 BRD-K07954936 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121211 BRD-K07954936 HA1E 0.37 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.73
121262 BRD-K07954936 HELA 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
121301 BRD-K07954936 PC3 0.37 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
121340 BRD-K07954936 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129286 BRD-K07954936 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129323 BRD-K07954936 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).