CMap Candidate Details

Structure:
CMap ID: C04926
Pert ID: BRD-K07955840
Compound Name: PF-05212384
Targets: MTOR; PIK3CA
MoA: MTOR inhibitor; PI3K inhibitor
SMILES: CN(C)C1CCN(CC1)C(=O)c1ccc(NC(=O)Nc2ccc(cc2)-c2nc(nc(n2)N2CCOCC2)N2CCOCC2)cc1
InchiKey: DWZAEMINVBZMHQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
515 BRD-K07955840 BJAB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
563 BRD-K07955840 HBL1 2.5 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
608 BRD-K07955840 K562 2.5 uM 4 h -0.21 -0.88 0.03 -0.34 -1.16 1.11
653 BRD-K07955840 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
699 BRD-K07955840 MINO 2.5 uM 24 h 0.0 0.0 0.0 -0.19 -0.65 0.01
747 BRD-K07955840 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
775 BRD-K07955840 OCILY19 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
820 BRD-K07955840 OCILY3 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
889 BRD-K07955840 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.62
930 BRD-K07955840 THP1 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
976 BRD-K07955840 TMD8 10 uM 4 h 0.24 1.01 0.12 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).