CMap Candidate Details

Structure:
CMap ID: C04936
Pert ID: BRD-K07996107
Compound Name: harpagoside
Targets: NOS2; PTGS2
MoA: Acetylcholinesterase inhibitor
SMILES: C[C@@]1(C[C@@H](O)[C@]2(O)C=CO[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]12)OC(=O)/C=C/c4ccccc4
InchiKey: KVRQGMOSZKPBNS-FMHLWDFHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4047 BRD-K07996107 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4540 BRD-K07996107 HCC515 10 uM 6 h 0.25 1.06 0.19 0.0 0.0 0.0
4640 BRD-K07996107 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4885 BRD-K07996107 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37118 BRD-K07996107 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37365 BRD-K07996107 A549 10 uM 6 h 0.25 1.04 0.15 -0.43 -1.46 15.35
37587 BRD-K07996107 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37869 BRD-K07996107 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38049 BRD-K07996107 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38248 BRD-K07996107 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38422 BRD-K07996107 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38686 BRD-K07996107 PHH 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
38909 BRD-K07996107 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).