CMap Candidate Details

Structure:
CMap ID: C00495
Pert ID: BRD-A19661776
Compound Name: mianserin
Targets: ADRA1D; ADRA1B; ADRA1A; DRD2; HRH1; HTR1A; HTR2A; HTR2B; HTR2C; HTR6; HTR7
MoA: Serotonin receptor antagonist
SMILES: CN1CCN2C(C1)c1ccccc1Cc1ccccc21
InchiKey: UEQUQVLFIPOEMF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3311 BRD-A19661776 HCC515 10 uM 6 h 0.0 0.0 0.0 0.21 0.73 0.03
3669 BRD-A19661776 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.79 0.11
39553 BRD-A19661776 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40561 BRD-A19661776 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.19 -0.66 0.01
40685 BRD-A19661776 NEU 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
40979 BRD-A19661776 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41302 BRD-A19661776 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90902 BRD-A19661776 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
120855 BRD-A19661776 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120900 BRD-A19661776 HA1E 1.11 uM 24 h -0.25 -1.03 0.19 0.0 0.0 0.0
120933 BRD-A19661776 HEK293 0.04 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
121066 BRD-A19661776 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121091 BRD-A19661776 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129107 BRD-A19661776 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129159 BRD-A19661776 HELA 0.25 uM 3 h 0.0 0.0 0.0 0.34 1.2 1.1
129181 BRD-A19661776 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).