CMap Candidate Details

Structure:
CMap ID: C04977
Pert ID: BRD-K08132273
Compound Name: tyrphostin
Targets: ERBB2
MoA: EGFR inhibitor
SMILES: COc1cc(C=C(C#N)C(=O)N)cc(CSc2nc3ccccc3s2)c1O
InchiKey: KXDONFLNGBQLTN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1538 BRD-K08132273 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2076 BRD-K08132273 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2529 BRD-K08132273 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41716 BRD-K08132273 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42051 BRD-K08132273 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42281 BRD-K08132273 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43475 BRD-K08132273 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43779 BRD-K08132273 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44060 BRD-K08132273 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100028 BRD-K08132273 U2OS 10 uM 6 h -0.2 -0.85 0.01 0.0 0.0 0.0
119646 BRD-K08132273 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
119684 BRD-K08132273 HT29 0.04 uM 24 h -0.24 -1.01 0.16 0.0 0.0 0.0
119724 BRD-K08132273 JURKAT 10 uM 24 h -0.26 -1.07 0.27 -0.25 -0.85 0.19
119773 BRD-K08132273 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.39
119809 BRD-K08132273 PC3 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).