CMap Candidate Details

Structure:
CMap ID: C05036
Pert ID: BRD-K08316444
Compound Name: rotenone
Targets: ND1
MoA: Mitochondrial complex I inhibitor
SMILES: COc1cc2OC[C@H]3Oc4c5C[C@@H](Oc5ccc4C(=O)[C@H]3c2cc1OC)C(=C)C
InchiKey: JUVIOZPCNVVQFO-HBGVWJBISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8905 BRD-K08316444 A375 0.66 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.23
9172 BRD-K08316444 A549 0.66 uM 6 h 0.0 0.0 0.0 -0.31 -1.06 0.73
9659 BRD-K08316444 H1299 0.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10030 BRD-K08316444 HA1E 0.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10229 BRD-K08316444 HCC515 0.66 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
11410 BRD-K08316444 NCIH2073 0.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11705 BRD-K08316444 NCIH508 0.66 uM 6 h 0.0 0.0 0.0 0.3 1.08 0.65
11979 BRD-K08316444 NCIH596 0.66 uM 6 h 0.22 0.93 0.05 0.0 0.0 0.0
12725 BRD-K08316444 SW480 0.66 uM 6 h 0.28 1.15 0.34 -0.34 -1.14 1.01
13081 BRD-K08316444 THP1 0.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13203 BRD-K08316444 U937 0.66 uM 6 h 0.0 0.0 0.0 0.31 1.09 0.67
13446 BRD-K08316444 VCAP 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52954 BRD-K08316444 HEPG2 40 uM 3 h -0.26 -1.1 0.33 0.0 0.0 0.0
53351 BRD-K08316444 MCF10A 30 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
53499 BRD-K08316444 HUH7 0.66 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
53643 BRD-K08316444 PHH 0.66 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
98998 BRD-K08316444 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99218 BRD-K08316444 NPC 10 uM 6 h 0.22 0.92 0.04 -0.31 -1.06 0.73
100032 BRD-K08316444 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.6
119685 BRD-K08316444 HT29 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119727 BRD-K08316444 JURKAT 0.05 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119775 BRD-K08316444 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 -0.37 -1.26 1.36
119810 BRD-K08316444 PC3 0.125 uM 24 h -0.25 -1.05 0.23 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).