CMap Candidate Details

Structure:
CMap ID: C05066
Pert ID: BRD-K08417745
Compound Name: SID-26681509
Targets: CTSL
MoA: Cathepsin inhibitor
SMILES: CCc1ccccc1NC(=O)CSC(=O)NNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC(C)(C)C
InchiKey: OTIWAYTTYNFEKL-JOCHJYFZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9027 BRD-K08417745 A375 90 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9173 BRD-K08417745 A549 90 uM 6 h -0.34 -1.4 1.14 0.0 0.0 0.0
9352 BRD-K08417745 AGS 90 uM 6 h -0.2 -0.84 0.0 0.27 0.96 0.33
9660 BRD-K08417745 H1299 90 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9894 BRD-K08417745 HA1E 90 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10272 BRD-K08417745 HCC515 90 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10455 BRD-K08417745 HCT116 90 uM 6 h -0.17 -0.71 0.0 0.0 0.0 0.0
10723 BRD-K08417745 HEPG2 90 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10939 BRD-K08417745 HT29 90 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11263 BRD-K08417745 MCF??7.00 90 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11411 BRD-K08417745 NCIH2073 90 uM 6 h -0.2 -0.83 0.0 0.3 1.04 0.56
11980 BRD-K08417745 NCIH596 90 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.17
12260 BRD-K08417745 NOMO1 90 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12456 BRD-K08417745 PC3 90 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12726 BRD-K08417745 SW480 90 uM 6 h 0.0 0.0 0.0 0.26 0.92 0.25
12965 BRD-K08417745 THP1 90 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13575 BRD-K08417745 VCAP 90 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).