CMap Candidate Details

Structure:
CMap ID: C00508
Pert ID: BRD-A20126139
Compound Name: medrysone
Targets: NR3C1
MoA: Glucocorticoid receptor agonist
SMILES: C[C@H]1CC2C3CC[C@H](C(C)=O)[C@@]3(C)C[C@H](O)C2[C@@]2(C)CCC(=O)C=C12
InchiKey: GZENKSODFLBBHQ-IENIWFQZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3090 BRD-A20126139 HCC515 10 uM 24 h -0.28 -1.17 0.48 -0.32 -1.06 0.74
3670 BRD-A20126139 VCAP 10 uM 24 h -0.21 -0.85 0.01 0.0 0.0 0.0
44751 BRD-A20126139 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45071 BRD-A20126139 HEPG2 10 uM 6 h 0.24 1.0 0.11 0.0 0.0 0.0
45871 BRD-A20126139 NPC 10 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
46183 BRD-A20126139 PHH 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.66 0.01
46500 BRD-A20126139 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120860 BRD-A20126139 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120885 BRD-A20126139 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120906 BRD-A20126139 HA1E 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120943 BRD-A20126139 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121012 BRD-A20126139 HT29 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.02
121035 BRD-A20126139 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
121101 BRD-A20126139 YAPC 0.125 uM 24 h -0.33 -1.36 1.06 -0.28 -0.95 0.42
129147 BRD-A20126139 HELA 0.03 uM 24 h 0.0 0.0 0.0 -0.22 -0.76 0.07
129217 BRD-A20126139 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).