CMap Candidate Details

Structure:
CMap ID: C05112
Pert ID: BRD-K08554278
Compound Name: bisbenzimide
Targets: TOP1
MoA: DNA binding agent
SMILES: CCOc1ccc(cc1)c2nc3cc(ccc3[nH]2)c4nc5cc(ccc5[nH]4)N6CCN(C)CC6
InchiKey: KTHLBVBTGUUEFS-DIBXZPPDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4190 BRD-K08554278 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4542 BRD-K08554278 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4771 BRD-K08554278 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5026 BRD-K08554278 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44293 BRD-K08554278 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44665 BRD-K08554278 A549 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.84 0.17
44842 BRD-K08554278 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45150 BRD-K08554278 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45417 BRD-K08554278 HT29 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.7 0.03
45646 BRD-K08554278 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45956 BRD-K08554278 NPC 10 uM 24 h -0.26 -1.09 0.33 -0.32 -1.08 0.81
46276 BRD-K08554278 PHH 10 uM 24 h 0.22 0.92 0.04 0.28 1.0 0.42
46591 BRD-K08554278 SKB 10 uM 24 h -0.27 -1.11 0.37 0.0 0.0 0.0
100036 BRD-K08554278 U2OS 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).