CMap Candidate Details

Structure:
CMap ID: C05120
Pert ID: BRD-K08589866
Compound Name: linsitinib
Targets: IGF1R; INSR
MoA: IGF-1 inhibitor
SMILES: CC1(C)CC(C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12
InchiKey: RGLPLEBXLNEXKU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9176 BRD-K08589866 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9355 BRD-K08589866 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9661 BRD-K08589866 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9958 BRD-K08589866 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10210 BRD-K08589866 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10457 BRD-K08589866 HCT116 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.96 0.44
10726 BRD-K08589866 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.86 0.22
10941 BRD-K08589866 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11264 BRD-K08589866 MCF??7.00 10 uM 6 h -0.26 -1.09 0.33 0.24 0.84 0.12
11414 BRD-K08589866 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11707 BRD-K08589866 NCIH508 10 uM 6 h 0.16 0.68 0.0 0.0 0.0 0.0
11983 BRD-K08589866 NCIH596 10 uM 6 h -0.21 -0.87 0.02 -0.3 -1.02 0.6
12263 BRD-K08589866 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12727 BRD-K08589866 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13056 BRD-K08589866 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13447 BRD-K08589866 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.03
96503 BRD-K08589866 A375 10 uM 24 h 0.0 0.0 0.0 -0.46 -1.55 15.35
96572 BRD-K08589866 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).