CMap Candidate Details

Structure:
CMap ID: C00515
Pert ID: BRD-A20243730
Compound Name: danazol
Targets: ESR1; GNRHR
MoA: Estrogen receptor antagonist; Progesterone receptor agonist
SMILES: CC12CCC3C(CCC4=Cc5oncc5CC34C)C2CCC1(O)C#C
InchiKey: POZRVZJJTULAOH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2798 BRD-A20243730 HA1E 10 uM 24 h 0.0 0.0 0.0 0.18 0.63 0.0
3091 BRD-A20243730 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3580 BRD-A20243730 PC3 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.07 0.75
3671 BRD-A20243730 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
39035 BRD-A20243730 A375 10 uM 6 h 0.25 1.06 0.18 -0.27 -0.91 0.31
39265 BRD-A20243730 A549 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
39554 BRD-A20243730 ASC 10 uM 24 h -0.27 -1.13 0.41 0.0 0.0 0.0
39883 BRD-A20243730 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40168 BRD-A20243730 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40422 BRD-A20243730 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40686 BRD-A20243730 NEU 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.16
40980 BRD-A20243730 NPC 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.4 2.02
41303 BRD-A20243730 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).