CMap Candidate Details

Structure:
CMap ID: C05175
Pert ID: BRD-K08799216
Compound Name: pelitinib
Targets: EGFR
MoA: EGFR inhibitor
SMILES: CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=CCN(C)C
InchiKey: WVUNYSQLFKLYNI-AATRIKPKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91994 BRD-K08799216 A375 0.12 uM 24 h 0.2 0.82 0.0 -0.34 -1.15 1.05
92022 BRD-K08799216 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92070 BRD-K08799216 HA1E 3.33 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
92104 BRD-K08799216 HCC515 3.33 uM 24 h 0.21 0.86 0.01 0.28 1.0 0.42
92141 BRD-K08799216 HS578T 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92191 BRD-K08799216 HT29 0.37 uM 24 h 0.26 1.09 0.22 0.22 0.78 0.06
92235 BRD-K08799216 MCF10A 1.11 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92257 BRD-K08799216 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92291 BRD-K08799216 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92342 BRD-K08799216 PC3 0.04 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
92370 BRD-K08799216 SKBR3 0.12 uM 24 h -0.29 -1.21 0.58 0.0 0.0 0.0
121182 BRD-K08799216 A549 10 uM 24 h -0.24 -1.0 0.14 0.0 0.0 0.0
129271 BRD-K08799216 HELA 2.22 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
129366 BRD-K08799216 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).