CMap Candidate Details

Structure:
CMap ID: C05181
Pert ID: BRD-K08806317
Compound Name: timolol
Targets: ADRB1; ADRB2
MoA: Adrenergic receptor antagonist
SMILES: CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1
InchiKey: BLJRIMJGRPQVNF-JTQLQIEISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4052 BRD-K08806317 HA1E 10 uM 24 h -0.23 -0.97 0.1 -0.32 -1.08 0.79
44297 BRD-K08806317 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44845 BRD-K08806317 ASC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.66
45154 BRD-K08806317 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45421 BRD-K08806317 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45960 BRD-K08806317 NPC 10 uM 24 h 0.0 0.0 0.0 0.37 1.29 1.49
46280 BRD-K08806317 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46595 BRD-K08806317 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
49980 BRD-K08806317 A549 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.23 1.25
50336 BRD-K08806317 HCC515 10 uM 6 h 0.26 1.1 0.24 0.0 0.0 0.0
50907 BRD-K08806317 PC3 10 uM 6 h -0.26 -1.06 0.26 0.0 0.0 0.0
51007 BRD-K08806317 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
52121 BRD-K08806317 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91053 BRD-K08806317 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).