CMap Candidate Details

Structure:
CMap ID: C05194
Pert ID: BRD-K08845546
Compound Name: tacrolimus
Targets: FKBP1A
MoA: Calcineurin inhibitor
SMILES: CO[C@@H]1C[C@@H](CC[C@H]1O)C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@H](C[C@H](C[C@@H](C)CC(C)=C/[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC)[C@H](C[C@H]2C)OC
InchiKey: KDEJOJSUWQBZSP-JWZPFBAESA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8908 BRD-K08845546 A375 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9177 BRD-K08845546 A549 20 uM 6 h 0.0 0.0 0.0 -0.37 -1.24 1.3
9356 BRD-K08845546 AGS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9663 BRD-K08845546 H1299 20 uM 6 h 0.17 0.73 0.0 0.0 0.0 0.0
9975 BRD-K08845546 HA1E 20 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
10343 BRD-K08845546 HCC515 20 uM 6 h -0.22 -0.91 0.05 -0.2 -0.67 0.02
10458 BRD-K08845546 HCT116 20 uM 6 h 0.0 0.0 0.0 -0.17 -0.59 0.0
10728 BRD-K08845546 HEPG2 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10942 BRD-K08845546 HT29 20 uM 24 h -0.23 -0.97 0.11 0.24 0.84 0.13
11224 BRD-K08845546 MCF??7.00 20 uM 24 h 0.17 0.69 0.0 0.0 0.0 0.0
11985 BRD-K08845546 NCIH596 20 uM 6 h -0.26 -1.08 0.31 0.0 0.0 0.0
12265 BRD-K08845546 NOMO1 20 uM 6 h 0.0 0.0 0.0 0.36 1.28 1.42
12549 BRD-K08845546 PC3 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12728 BRD-K08845546 SW480 20 uM 6 h 0.0 0.0 0.0 -0.38 -1.27 1.39
13077 BRD-K08845546 THP1 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13207 BRD-K08845546 U937 20 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.27
13448 BRD-K08845546 VCAP 20 uM 24 h -0.31 -1.27 0.74 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).