CMap Candidate Details

Structure:
CMap ID: C05214
Pert ID: BRD-K08924299
Compound Name: palonosetron
Targets: HTR3A
MoA: Serotonin receptor antagonist
SMILES: O=C1N(C[C@H]2CCCc3cccc1c23)[C@@H]1CN2CCC1CC2
InchiKey: CPZBLNMUGSZIPR-NVXWUHKLSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
22240 BRD-K08924299 A549 10 uM 6 h -0.16 -0.68 0.0 0.0 0.0 0.0
22695 BRD-K08924299 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22978 BRD-K08924299 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24116 BRD-K08924299 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
121147 BRD-K08924299 A375 0.125 uM 24 h -0.26 -1.09 0.32 0.0 0.0 0.0
121220 BRD-K08924299 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121267 BRD-K08924299 HELA 0.37 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
121277 BRD-K08924299 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129329 BRD-K08924299 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
129351 BRD-K08924299 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.11
129367 BRD-K08924299 YAPC 0.74 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).