CMap Candidate Details

Structure:
CMap ID: C00528
Pert ID: BRD-A20697603
Compound Name: thiostrepton
Targets: FOXM1
MoA: FOXM1 inhibitor; Protein synthesis inhibitor
SMILES: CCC(C)C1NC2C=Cc3c(cc(nc3C2O)C(=O)OC(C)C2NC(=O)c3csc(n3)C(NC(=O)C3CSC(=N3)C(NC(=O)C(NC(=O)c3csc(n3)C3(CCC(=NC3c3csc2n3)c2nc(cs2)C(=O)NC(=C)C(=O)NC(=C)C(N)=O)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC1=O)C(C)O)=C/C)C(C)(O)C(C)O)C(C)O
InchiKey: NSFFHOGKXHRQEW-DVRIZHICSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25675 BRD-A20697603 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27158 BRD-A20697603 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
29047 BRD-A20697603 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33978 BRD-A20697603 ASC 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.86
34259 BRD-A20697603 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34492 BRD-A20697603 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34763 BRD-A20697603 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35449 BRD-A20697603 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35503 BRD-A20697603 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36038 BRD-A20697603 PC3 10 uM 6 h 0.0 0.0 0.0 0.37 1.32 1.59
36137 BRD-A20697603 PHH 10 uM 24 h 0.23 0.94 0.06 0.0 0.0 0.0
36928 BRD-A20697603 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96077 BRD-A20697603 A549 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
97684 BRD-A20697603 NKDBA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).