CMap Candidate Details

Structure:
CMap ID: C05284
Pert ID: BRD-K09132007
Compound Name: D-4476
Targets: CSNK1A1; TGFB1
MoA: TGF beta receptor inhibitor
SMILES: NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccccn1)-c1ccc2OCCOc2c1
InchiKey: DPDZHVCKYBCJHW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4356 BRD-K09132007 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4890 BRD-K09132007 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44669 BRD-K09132007 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46283 BRD-K09132007 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46599 BRD-K09132007 SKB 10 uM 24 h 0.27 1.12 0.27 0.35 1.24 1.27
94480 BRD-K09132007 ASC 0.37 uM 24 h 0.0 0.0 0.0 -0.33 -1.09 0.84
94546 BRD-K09132007 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94637 BRD-K09132007 HEK293 1.11 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
94741 BRD-K09132007 HME1 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
94833 BRD-K09132007 HUVEC 10 uM 24 h 0.26 1.06 0.19 0.0 0.0 0.0
94886 BRD-K09132007 JURKAT 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
94932 BRD-K09132007 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.38
94973 BRD-K09132007 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
95012 BRD-K09132007 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95075 BRD-K09132007 NPC 1.11 uM 24 h 0.0 0.0 0.0 -0.21 -0.69 0.02
95159 BRD-K09132007 SHSY5Y 10 uM 24 h -0.29 -1.2 0.55 0.0 0.0 0.0
95233 BRD-K09132007 SKL 10 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
95269 BRD-K09132007 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100045 BRD-K09132007 U2OS 10 uM 6 h 0.23 0.98 0.09 0.0 0.0 0.0
118750 BRD-K09132007 HA1E 20 uM 24 h -0.17 -0.73 0.0 0.0 0.0 0.0
118832 BRD-K09132007 HEPG2 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118874 BRD-K09132007 HT29 20 uM 24 h -0.22 -0.93 0.07 -0.23 -0.78 0.1
121151 BRD-K09132007 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121252 BRD-K09132007 HELA 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
121314 BRD-K09132007 PC3 3.33 uM 24 h 0.18 0.76 0.0 0.31 1.11 0.71
121345 BRD-K09132007 YAPC 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).