CMap Candidate Details

Structure:
CMap ID: C05296
Pert ID: BRD-K09186807
Compound Name: KIN001-244
Targets: PDPK1
MoA: Phosphoinositide dependent kinase inhibitor
SMILES: Fc1ccc(Cn2cccc(C(=O)N[C@@H](COc3ccc4[nH]c(=O)[nH]c4c3)c3ccccc3)c2=O)cc1F
InchiKey: AHMXYULEXZAPCS-VWLOTQADSA-N
Compound Aliases: KIN-001-244

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
34555 BRD-K09186807 HCC515 10 uM 6 h 0.19 0.8 0.0 0.39 1.38 2.16
35090 BRD-K09186807 HT29 10 uM 6 h 0.0 0.0 0.0 0.34 1.22 1.15
35420 BRD-K09186807 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36199 BRD-K09186807 PHH 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
36492 BRD-K09186807 SKB 10 uM 24 h -0.31 -1.29 0.78 0.0 0.0 0.0
36772 BRD-K09186807 VCAP 10 uM 24 h -0.25 -1.06 0.25 0.0 0.0 0.0
91533 BRD-K09186807 BT20 2.22 uM 6 h 0.0 0.0 0.0 -0.35 -1.19 1.16
91597 BRD-K09186807 HS578T 0.37 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91760 BRD-K09186807 SKBR3 0.08 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
92865 BRD-K09186807 A375 10 uM 24 h 0.18 0.73 0.0 -0.3 -1.01 0.56
92893 BRD-K09186807 A549 10 uM 24 h 0.0 0.0 0.0 -0.42 -1.4 2.02
92929 BRD-K09186807 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92992 BRD-K09186807 CD34 10 uM 24 h 0.0 0.0 0.0 -0.43 -1.45 15.35
93038 BRD-K09186807 HA1E 10 uM 24 h -0.18 -0.75 0.0 -0.44 -1.49 15.35
93080 BRD-K09186807 HEK293 10 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
93123 BRD-K09186807 HELA 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
93168 BRD-K09186807 HEPG2 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93218 BRD-K09186807 HUVEC 10 uM 24 h 0.25 1.06 0.19 -0.36 -1.22 1.25
93273 BRD-K09186807 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
93313 BRD-K09186807 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93355 BRD-K09186807 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93393 BRD-K09186807 NPC 10 uM 24 h 0.0 0.0 0.0 0.19 0.68 0.01
93443 BRD-K09186807 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93483 BRD-K09186807 SKL 10 uM 24 h -0.17 -0.73 0.0 -0.27 -0.9 0.29
93540 BRD-K09186807 THP1 10 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
93580 BRD-K09186807 YAPC 3.33 uM 24 h -0.22 -0.92 0.06 -0.28 -0.93 0.36
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).