CMap Candidate Details

Structure:
CMap ID: C05383
Pert ID: BRD-K09485525
Compound Name: GANT-61
Targets: GLI1; GLI2
MoA: GLI antagonist
SMILES: CN(C)c1ccccc1CN1CCCN(Cc2ccccc2N(C)C)C1c1ccncc1
InchiKey: KVQOGDQTWWCZFX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29783 BRD-K09485525 A375 10 uM 6 h 0.0 0.0 0.0 0.23 0.81 0.09
30164 BRD-K09485525 A549 10 uM 6 h 0.0 0.0 0.0 0.27 0.97 0.35
30361 BRD-K09485525 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30682 BRD-K09485525 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30964 BRD-K09485525 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.42
31267 BRD-K09485525 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31693 BRD-K09485525 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31835 BRD-K09485525 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32134 BRD-K09485525 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32352 BRD-K09485525 NPC 10 uM 24 h 0.3 1.26 0.58 -0.33 -1.11 0.92
32607 BRD-K09485525 PC3 10 uM 24 h 0.0 0.0 0.0 0.41 1.46 2.23
32942 BRD-K09485525 SKB 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.38
33243 BRD-K09485525 VCAP 10 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).