CMap Candidate Details

Structure:
CMap ID: C05387
Pert ID: BRD-K09499853
Compound Name: KU-0060648
Targets: PIK3CA; PIK3CB; PIK3CD; PRKDC
MoA: PI3K inhibitor; DNA dependent protein kinase inhibitor
SMILES: CCN1CCN(CC(=O)Nc2ccc(-c3cccc4c3oc(cc4=O)N3CCOCC3)c3sc4ccccc4c23)CC1
InchiKey: AATCBLYHOUOCTO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9018 BRD-K09499853 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9357 BRD-K09499853 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9664 BRD-K09499853 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10031 BRD-K09499853 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10109 BRD-K09499853 HCC515 10 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.25
10459 BRD-K09499853 HCT116 10 uM 6 h 0.17 0.71 0.0 -0.24 -0.8 0.12
10729 BRD-K09499853 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.33 1.18 0.97
11052 BRD-K09499853 HT29 10 uM 6 h 0.0 0.0 0.0 0.31 1.1 0.69
11416 BRD-K09499853 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.36 1.26 1.29
11986 BRD-K09499853 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12593 BRD-K09499853 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12729 BRD-K09499853 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12926 BRD-K09499853 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13208 BRD-K09499853 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13449 BRD-K09499853 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90566 BRD-K09499853 A549 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
90581 BRD-K09499853 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).