CMap Candidate Details

Structure:
CMap ID: C05402
Pert ID: BRD-K09549677
Compound Name: mibefradil
Targets: CACNA1C; CACNA1I; CACNA1H; CACNA1G
MoA: T-type calcium channel blocker
SMILES: COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C
InchiKey: HBNPJJILLOYFJU-VMPREFPWSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1734 BRD-K09549677 HA1E 10 uM 6 h 0.0 0.0 0.0 0.4 1.43 2.2
1879 BRD-K09549677 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42285 BRD-K09549677 ASC 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
42619 BRD-K09549677 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.3 1.05 0.57
43478 BRD-K09549677 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43783 BRD-K09549677 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44063 BRD-K09549677 SKB 10 uM 24 h 0.0 0.0 0.0 0.36 1.27 1.34
88533 BRD-K09549677 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.72 0.04
100051 BRD-K09549677 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121154 BRD-K09549677 A375 10 uM 24 h 0.3 1.24 0.53 0.0 0.0 0.0
121191 BRD-K09549677 A549 10 uM 24 h 0.0 0.0 0.0 0.43 1.51 2.27
121269 BRD-K09549677 HELA 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
121280 BRD-K09549677 HT29 10 uM 24 h 0.2 0.85 0.01 -0.18 -0.6 0.0
121319 BRD-K09549677 PC3 10 uM 24 h 0.23 0.98 0.09 0.0 0.0 0.0
121349 BRD-K09549677 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129337 BRD-K09549677 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).