CMap Candidate Details

Structure:
CMap ID: C05427
Pert ID: BRD-K09631521
Compound Name: thiotepa
Targets: CYP2B6; CYP3A4
MoA: Cytochrome P450 inhibitor
SMILES: S=P(N1CC1)(N1CC1)N1CC1
InchiKey: FOCVUCIESVLUNU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5300 BRD-K09631521 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5577 BRD-K09631521 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.73
6161 BRD-K09631521 PC3 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
6521 BRD-K09631521 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37120 BRD-K09631521 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37264 BRD-K09631521 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37589 BRD-K09631521 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38051 BRD-K09631521 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38247 BRD-K09631521 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38424 BRD-K09631521 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38687 BRD-K09631521 PHH 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
53004 BRD-K09631521 HEPG2 100 uM 48 h -0.25 -1.02 0.18 0.2 0.7 0.02
53144 BRD-K09631521 MCF10A 100 uM 48 h -0.28 -1.15 0.43 0.3 1.05 0.58
100053 BRD-K09631521 U2OS 10 uM 6 h -0.33 -1.38 1.08 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).