CMap Candidate Details

Structure:
CMap ID: C05502
Pert ID: BRD-K09900591
Compound Name: caffeic-acid
Targets: ALOX5
MoA: Lipoxygenase inhibitor; NFKB pathway inhibitor; HIV integrase inhibitor; PPAR receptor modulator; TNF production inhibitor; Nitric oxide production inhibitor; Tumor necrosis factor production inhibitor
SMILES: OC(=O)C=Cc1ccc(O)c(O)c1
InchiKey: QAIPRVGONGVQAS-DUXPYHPUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49808 BRD-K09900591 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50150 BRD-K09900591 HA1E 10 uM 6 h 0.23 0.96 0.07 0.0 0.0 0.0
50502 BRD-K09900591 HT29 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.45
50652 BRD-K09900591 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50909 BRD-K09900591 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
51127 BRD-K09900591 VCAP 10 uM 6 h 0.19 0.81 0.0 0.0 0.0 0.0
53005 BRD-K09900591 HEPG2 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
53067 BRD-K09900591 MCF10A 100 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).