CMap Candidate Details

Structure:
CMap ID: C05517
Pert ID: BRD-K09951645
Compound Name: dabrafenib
Targets: BRAF
MoA: RAF inhibitor
SMILES: CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
InchiKey: BFSMGDJOXZAERB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1165 BRD-K09951645 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1204 BRD-K09951645 PC3 10 uM 24 h 0.21 0.89 0.02 0.29 1.02 0.48
1231 BRD-K09951645 A549 10 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
1396 BRD-K09951645 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.14 1.03
94512 BRD-K09951645 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94548 BRD-K09951645 CD34 10 uM 24 h -0.2 -0.84 0.01 -0.36 -1.22 1.25
94639 BRD-K09951645 HEK293 10 uM 24 h 0.0 0.0 0.0 0.36 1.29 1.47
94689 BRD-K09951645 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94743 BRD-K09951645 HME1 10 uM 24 h 0.21 0.88 0.01 0.46 1.62 2.4
94835 BRD-K09951645 HUVEC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94888 BRD-K09951645 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94934 BRD-K09951645 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
95014 BRD-K09951645 NEU 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95076 BRD-K09951645 NPC 0.04 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.97
95161 BRD-K09951645 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.46
95208 BRD-K09951645 SKL 10 uM 24 h 0.22 0.9 0.02 0.0 0.0 0.0
95271 BRD-K09951645 THP1 0.12 uM 24 h 0.21 0.88 0.02 0.0 0.0 0.0
117345 BRD-K09951645 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117424 BRD-K09951645 HA1E 3.33 uM 24 h 0.27 1.15 0.32 0.0 0.0 0.0
117469 BRD-K09951645 HCC515 3.33 uM 24 h 0.0 0.0 0.0 -0.51 -1.73 15.65
117516 BRD-K09951645 HEPG2 3.33 uM 24 h -0.2 -0.84 0.01 -0.31 -1.05 0.7
129303 BRD-K09951645 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129377 BRD-K09951645 YAPC 0.08 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.81
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).