CMap Candidate Details

Structure:
CMap ID: C00553
Pert ID: BRD-A22032524
Compound Name: amlodipine
Targets: CACNA1C; CACNA1D; CACNA1S; CACNA2D1
MoA: Calcium channel blocker
SMILES: CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
InchiKey: HTIQEAQVCYTUBX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1226 BRD-A22032524 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1291 BRD-A22032524 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
1392 BRD-A22032524 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5506 BRD-A22032524 HCC515 10 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
6125 BRD-A22032524 PC3 10 uM 24 h 0.17 0.72 0.0 0.27 0.97 0.34
6455 BRD-A22032524 VCAP 10 uM 6 h 0.23 0.98 0.09 0.3 1.08 0.64
37049 BRD-A22032524 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37455 BRD-A22032524 ASC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.01
37792 BRD-A22032524 HEPG2 10 uM 6 h 0.32 1.32 0.84 0.0 0.0 0.0
38305 BRD-A22032524 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38608 BRD-A22032524 PHH 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
38830 BRD-A22032524 SKB 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
91029 BRD-A22032524 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
120951 BRD-A22032524 HEK293 10 uM 24 h -0.22 -0.9 0.05 0.0 0.0 0.0
120986 BRD-A22032524 HELA 10 uM 24 h 0.0 0.0 0.0 -0.45 -1.5 15.35
121017 BRD-A22032524 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121107 BRD-A22032524 YAPC 3.33 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
129134 BRD-A22032524 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).