CMap Candidate Details

Structure:
CMap ID: C05548
Pert ID: BRD-K10042277
Compound Name: desmethylclozapine
Targets: CHRM1; DRD2; DRD3; HTR2A; HTR2C
MoA: Acetylcholine receptor agonist
SMILES: Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCNCC1
InchiKey: JNNOSTQEZICQQP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2835 BRD-K10042277 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3333 BRD-K10042277 HCC515 10 uM 6 h 0.0 0.0 0.0 0.32 1.13 0.82
3594 BRD-K10042277 PC3 10 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.49
3724 BRD-K10042277 VCAP 10 uM 24 h 0.24 0.98 0.09 0.3 1.05 0.57
39091 BRD-K10042277 A375 10 uM 6 h -0.16 -0.68 0.0 -0.22 -0.72 0.04
39298 BRD-K10042277 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39628 BRD-K10042277 ASC 10 uM 24 h 0.0 0.0 0.0 0.39 1.36 1.75
39946 BRD-K10042277 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40227 BRD-K10042277 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40590 BRD-K10042277 MCF??7.00 10 uM 6 h 0.24 1.02 0.12 0.0 0.0 0.0
41051 BRD-K10042277 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41380 BRD-K10042277 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100060 BRD-K10042277 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).