CMap Candidate Details

Structure:
CMap ID: C00565
Pert ID: BRD-A22380646
Compound Name: pantoprazole
Targets: ATP4A
MoA: ATPase inhibitor
SMILES: COc1ccnc(CS(=O)c2nc3cc(OC(F)F)ccc3[nH]2)c1OC
InchiKey: IQPSEEYGBUAQFF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4514 BRD-A22380646 HCC515 10 uM 6 h 0.18 0.75 0.0 -0.24 -0.8 0.12
25469 BRD-A22380646 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37457 BRD-A22380646 ASC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.16 1.11
37793 BRD-A22380646 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38307 BRD-A22380646 NPC 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.36 2.02
38610 BRD-A22380646 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38832 BRD-A22380646 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91326 BRD-A22380646 HUH7 8 uM 72 h -0.25 -1.06 0.26 -0.34 -1.15 1.07
95499 BRD-A22380646 A549 0.12 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
95657 BRD-A22380646 U2OS 0.12 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
121527 BRD-A22380646 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
129412 BRD-A22380646 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129445 BRD-A22380646 HA1E 0.08 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.62
129471 BRD-A22380646 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129498 BRD-A22380646 HT29 0.01 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.23
129528 BRD-A22380646 MCF??7.00 0.74 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
129563 BRD-A22380646 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).