CMap Candidate Details

Structure:
CMap ID: C05661
Pert ID: BRD-K10467831
Compound Name: tibolone
Targets: ESR1; AR; PGR
MoA: Androgen receptor agonist; Estrogen receptor agonist; Progesterone receptor agonist
SMILES: C[C@@H]1CC2=C(CCC(=O)C2)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(O)C#C)[C@H]13
InchiKey: WZDGZWOAQTVYBX-XOINTXKNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
22020 BRD-K10467831 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22242 BRD-K10467831 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22431 BRD-K10467831 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22697 BRD-K10467831 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
22980 BRD-K10467831 HEPG2 10 uM 6 h 0.22 0.92 0.04 0.19 0.68 0.01
23287 BRD-K10467831 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
23545 BRD-K10467831 MCF??7.00 10 uM 24 h 0.18 0.77 0.0 0.0 0.0 0.0
23964 BRD-K10467831 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24117 BRD-K10467831 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91219 BRD-K10467831 HUH7 10 uM 72 h 0.0 0.0 0.0 0.23 0.8 0.08
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).