CMap Candidate Details

Structure:
CMap ID: C05713
Pert ID: BRD-K10670311
Compound Name: sulfasalazine
Targets: ALOX5; PTGS1; PTGS2
MoA: Anti-rheumatic drug; NFKB pathway inhibitor
SMILES: OC(=O)c1cc(ccc1O)N=Nc1ccc(cc1)S(=O)(=O)Nc1ccccn1
InchiKey: NCEXYHBECQHGNR-QZQOTICOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24554 BRD-K10670311 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25490 BRD-K10670311 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91488 BRD-K10670311 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
100068 BRD-K10670311 U2OS 10 uM 6 h -0.26 -1.06 0.26 0.0 0.0 0.0
121160 BRD-K10670311 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121230 BRD-K10670311 HA1E 0.125 uM 24 h -0.24 -0.98 0.12 0.0 0.0 0.0
121271 BRD-K10670311 HELA 0.125 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
121292 BRD-K10670311 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121353 BRD-K10670311 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.29 1.03 0.51
129309 BRD-K10670311 HT29 2.22 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
129357 BRD-K10670311 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.42
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).