CMap Candidate Details

Structure:
CMap ID: C00577
Pert ID: BRD-A22783572
Compound Name: vinblastine
Targets: TUBB
MoA: Tubulin inhibitor; Microtubule inhibitor
SMILES: CCC1(O)CC2CN(C1)CCc3c([nH]c4ccccc34)C(C2)(C(=O)OC)c5cc6c(cc5OC)N(C)C7C86CCN9CC=CC(CC)(C98)C(C(=O)OC)C7(O)C(=O)OC
InchiKey: SLIRURSWQCRWFG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1487 BRD-A22783572 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2032 BRD-A22783572 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.81 0.12
2293 BRD-A22783572 PC3 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
2628 BRD-A22783572 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39037 BRD-A22783572 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39266 BRD-A22783572 A549 10 uM 24 h -0.22 -0.92 0.06 0.35 1.23 1.19
39556 BRD-A22783572 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39885 BRD-A22783572 HEPG2 10 uM 6 h -0.25 -1.03 0.19 -0.29 -0.99 0.5
40170 BRD-A22783572 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40423 BRD-A22783572 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
40688 BRD-A22783572 NEU 10 uM 24 h 0.3 1.26 0.57 0.0 0.0 0.0
40982 BRD-A22783572 NPC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.71
41305 BRD-A22783572 SKB 10 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.41
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).