CMap Candidate Details

Structure:
CMap ID: C05802
Pert ID: BRD-K10916986
Compound Name: vinorelbine
Targets: TUBB
MoA: Tubulin inhibitor
SMILES: CCC1=C[C@@H]2C[N@](C1)Cc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
InchiKey: GBABOYUKABKIAF-JEEMQKELSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33583 BRD-K10916986 A375 10 uM 6 h 0.24 0.98 0.09 -0.38 -1.27 1.43
33777 BRD-K10916986 A549 10 uM 24 h 0.0 0.0 0.0 0.33 1.15 0.9
34045 BRD-K10916986 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34313 BRD-K10916986 HA1E 10 uM 6 h 0.2 0.83 0.0 0.0 0.0 0.0
34560 BRD-K10916986 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.41
34828 BRD-K10916986 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.98 0.47
35094 BRD-K10916986 HT29 10 uM 6 h 0.22 0.92 0.04 0.0 0.0 0.0
35405 BRD-K10916986 MCF??7.00 10 uM 6 h 0.27 1.13 0.28 0.0 0.0 0.0
35540 BRD-K10916986 NEU 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.73
35730 BRD-K10916986 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35931 BRD-K10916986 PC3 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
36204 BRD-K10916986 PHH 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.5
36497 BRD-K10916986 SKB 10 uM 24 h -0.26 -1.08 0.28 0.0 0.0 0.0
36776 BRD-K10916986 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).