CMap Candidate Details

Structure:
CMap ID: C00586
Pert ID: BRD-A23226398
Compound Name: estradiol
Targets: ESR1; ESR2; NR1I2
MoA: Estrogen receptor agonist
SMILES: CC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C
InchiKey: QAHOQNJVHDHYRN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4159 BRD-A23226398 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
4515 BRD-A23226398 HCC515 10 uM 6 h -0.24 -0.98 0.12 0.0 0.0 0.0
4738 BRD-A23226398 PC3 10 uM 6 h -0.18 -0.75 0.0 0.0 0.0 0.0
4983 BRD-A23226398 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.2 -0.68 0.02
37050 BRD-A23226398 A375 10 uM 6 h 0.0 0.0 0.0 0.32 1.15 0.88
37218 BRD-A23226398 A549 10 uM 24 h 0.22 0.91 0.04 0.22 0.79 0.08
37458 BRD-A23226398 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37794 BRD-A23226398 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37989 BRD-A23226398 HT29 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.19 1.15
38134 BRD-A23226398 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38308 BRD-A23226398 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38833 BRD-A23226398 SKB 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).