CMap Candidate Details

Structure:
CMap ID: C05979
Pert ID: BRD-K11528507
Compound Name: geldanamycin
Targets: HSP90AA1
MoA: HSP inhibitor
SMILES: CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)C(C)=CC=C/[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1O)C2=O
InchiKey: QTQAWLPCGQOSGP-KSRBKZBZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95906 BRD-K11528507 YAPC 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99002 BRD-K11528507 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99220 BRD-K11528507 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115023 BRD-K11528507 U2OS 20 uM 6 h 0.0 0.0 0.0 -0.23 -0.76 0.08
115493 BRD-K11528507 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115884 BRD-K11528507 MCF??7.00 10 uM 24 h -0.28 -1.17 0.5 -0.28 -0.96 0.43
116002 BRD-K11528507 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116290 BRD-K11528507 A375 10 uM 24 h 0.0 0.0 0.0 0.37 1.29 1.49
116783 BRD-K11528507 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117407 BRD-K11528507 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.88
117622 BRD-K11528507 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117853 BRD-K11528507 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.66 0.01
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).