CMap Candidate Details

Structure:
CMap ID: C00598
Pert ID: BRD-A23723433
Compound Name: paclitaxel
Targets: TUBB; NR1I2
MoA: Tubulin inhibitor
SMILES: CC(=O)OC1C2=C(C)C(CC(O)(C(OC(=O)c3ccccc3)C4C5(COC5CC(O)C4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)C(O)C(NC(=O)c6ccccc6)c7ccccc7
InchiKey: RCINICONZNJXQF-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1488 BRD-A23723433 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1816 BRD-A23723433 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2280 BRD-A23723433 PC3 10 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.85
2762 BRD-A23723433 VCAP 10 uM 6 h 0.0 0.0 0.0 0.2 0.71 0.02
41653 BRD-A23723433 A375 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.79 0.11
41874 BRD-A23723433 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42187 BRD-A23723433 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42532 BRD-A23723433 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42840 BRD-A23723433 HT29 10 uM 6 h 0.0 0.0 0.0 0.3 1.06 0.6
43117 BRD-A23723433 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43387 BRD-A23723433 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43702 BRD-A23723433 PHH 10 uM 24 h -0.35 -1.45 1.43 0.25 0.88 0.18
43999 BRD-A23723433 SKB 10 uM 24 h -0.22 -0.91 0.05 -0.29 -0.98 0.48
90708 BRD-A23723433 U937 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90759 BRD-A23723433 HPTEC 3.33 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).