CMap Candidate Details

Structure:
CMap ID: C05987
Pert ID: BRD-K11558771
Compound Name: droxinostat
Targets: HDAC6; HDAC8
MoA: HDAC inhibitor
SMILES: Cc1cc(Cl)ccc1OCCCC(=O)NO
InchiKey: JHSXDAWGLCZYSM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
49811 BRD-K11558771 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50154 BRD-K11558771 HA1E 10 uM 6 h -0.27 -1.11 0.36 0.0 0.0 0.0
50341 BRD-K11558771 HCC515 10 uM 6 h 0.23 0.97 0.08 0.25 0.88 0.19
50505 BRD-K11558771 HT29 10 uM 6 h 0.0 0.0 0.0 0.34 1.19 1.05
50736 BRD-K11558771 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.77 0.09
50912 BRD-K11558771 PC3 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.41
51129 BRD-K11558771 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95977 BRD-K11558771 PHH 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96113 BRD-K11558771 A549 10 uM 24 h -0.22 -0.91 0.05 0.26 0.9 0.22
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).