CMap Candidate Details

Structure:
CMap ID: C00600
Pert ID: BRD-A23770159
Compound Name: sirolimus
Targets: FKBP1A; MTOR
MoA: MTOR inhibitor
SMILES: CO[C@@H]1CC(CC(C)[C@@H]2CC(=O)[C@H](C)C=C(C)[C@@H](O)[C@@H](OC)C(=O)[C@@H](C)C[C@H](C)C=CC=CC=C(C)/[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O
InchiKey: QFJCIRLUMZQUOT-GWUMUYGYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9032 BRD-A23770159 A375 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9140 BRD-A23770159 A549 12 uM 6 h -0.34 -1.4 1.14 0.0 0.0 0.0
9278 BRD-A23770159 AGS 12 uM 6 h 0.0 0.0 0.0 -0.21 -0.7 0.03
9582 BRD-A23770159 H1299 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10004 BRD-A23770159 HA1E 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10157 BRD-A23770159 HCC515 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10389 BRD-A23770159 HCT116 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10659 BRD-A23770159 HEPG2 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11073 BRD-A23770159 HT29 12 uM 6 h 0.0 0.0 0.0 0.28 0.98 0.37
11168 BRD-A23770159 MCF??7.00 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11330 BRD-A23770159 NCIH2073 12 uM 6 h -0.25 -1.03 0.19 0.27 0.95 0.32
11646 BRD-A23770159 NCIH508 12 uM 6 h 0.0 0.0 0.0 0.23 0.82 0.1
11900 BRD-A23770159 NCIH596 12 uM 6 h 0.0 0.0 0.0 0.31 1.09 0.67
12197 BRD-A23770159 NOMO1 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12578 BRD-A23770159 PC3 12 uM 6 h 0.0 0.0 0.0 0.3 1.07 0.63
12998 BRD-A23770159 THP1 12 uM 6 h 0.21 0.87 0.01 0.0 0.0 0.0
13136 BRD-A23770159 U937 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13527 BRD-A23770159 VCAP 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).