CMap Candidate Details

Structure:
CMap ID: C06112
Pert ID: BRD-K11911061
Compound Name: GR-127935
Targets: HTR1A; HTR1B; HTR1D; HTR2A; HTR2C
MoA: Serotonin receptor antagonist
SMILES: COc1ccc(NC(=O)c2ccc(cc2)-c2ccc(cc2C)-c2noc(C)n2)cc1N1CCN(C)CC1
InchiKey: YDBCEBYHYKAFRX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1547 BRD-K11911061 HA1E 10 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.31
1888 BRD-K11911061 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2374 BRD-K11911061 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2612 BRD-K11911061 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41725 BRD-K11911061 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41912 BRD-K11911061 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42297 BRD-K11911061 ASC 10 uM 24 h -0.28 -1.16 0.46 0.0 0.0 0.0
42630 BRD-K11911061 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42933 BRD-K11911061 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43159 BRD-K11911061 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43490 BRD-K11911061 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44070 BRD-K11911061 SKB 10 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.76
100086 BRD-K11911061 U2OS 10 uM 6 h 0.23 0.95 0.07 0.28 0.98 0.37
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).