CMap Candidate Details

Structure:
CMap ID: C06118
Pert ID: BRD-K11927976
Compound Name: ER-27319
Targets: SYK
MoA: Syk inhibitor; Mediator release inhibitor
SMILES: Cc1ccc2c(c1C)n(CCCN)c1ccccc1c2=O
InchiKey: CFPDEQBPNROZDC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1740 BRD-K11927976 HA1E 10 uM 6 h 0.0 0.0 0.0 0.35 1.23 1.21
2081 BRD-K11927976 HCC515 10 uM 6 h 0.0 0.0 0.0 0.44 1.57 2.34
2375 BRD-K11927976 PC3 10 uM 6 h 0.0 0.0 0.0 0.32 1.14 0.87
41726 BRD-K11927976 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42060 BRD-K11927976 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42298 BRD-K11927976 ASC 10 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
42631 BRD-K11927976 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42934 BRD-K11927976 HT29 10 uM 6 h 0.0 0.0 0.0 0.33 1.18 0.98
43294 BRD-K11927976 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43794 BRD-K11927976 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44071 BRD-K11927976 SKB 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.26
100087 BRD-K11927976 U2OS 10 uM 6 h 0.0 0.0 0.0 0.24 0.86 0.16
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).