CMap Candidate Details

Structure:
CMap ID: C06194
Pert ID: BRD-K12184916
Compound Name: NVP-BEZ235
Targets: MTOR; PIK3CA; PIK3CD; PIK3CG
MoA: MTOR inhibitor; PI3K inhibitor
SMILES: Cn1c2cnc3ccc(cc3c2n(-c2ccc(cc2)C(C)(C)C#N)c1=O)-c1cnc2ccccc2c1
InchiKey: JOGKUKXHTYWRGZ-UHFFFAOYSA-N
Compound Aliases: dactolisib

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
492 BRD-K12184916 BJAB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
532 BRD-K12184916 HBL1 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.36
573 BRD-K12184916 K562 10 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
630 BRD-K12184916 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
675 BRD-K12184916 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
723 BRD-K12184916 NALM6 2.5 uM 24 h 0.0 0.0 0.0 0.26 0.94 0.28
789 BRD-K12184916 OCILY19 0.66 uM 4 h -0.21 -0.86 0.01 -0.38 -1.27 1.39
808 BRD-K12184916 OCILY3 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.22
864 BRD-K12184916 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
938 BRD-K12184916 TMD8 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.37
9364 BRD-K12184916 AGS 0.66 uM 6 h -0.28 -1.18 0.5 0.0 0.0 0.0
9671 BRD-K12184916 H1299 0.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10345 BRD-K12184916 HCC515 0.66 uM 6 h -0.2 -0.85 0.01 -0.36 -1.21 1.24
10735 BRD-K12184916 HEPG2 0.66 uM 6 h 0.0 0.0 0.0 -0.35 -1.17 1.11
11423 BRD-K12184916 NCIH2073 0.66 uM 6 h -0.25 -1.03 0.2 0.0 0.0 0.0
11714 BRD-K12184916 NCIH508 0.66 uM 6 h 0.0 0.0 0.0 0.28 0.99 0.4
11991 BRD-K12184916 NCIH596 0.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12270 BRD-K12184916 NOMO1 0.66 uM 6 h 0.0 0.0 0.0 -0.26 -0.89 0.26
12735 BRD-K12184916 SW480 0.66 uM 6 h 0.24 1.0 0.1 -0.36 -1.2 1.21
13085 BRD-K12184916 THP1 0.66 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.27
13214 BRD-K12184916 U937 0.66 uM 6 h 0.24 1.01 0.12 0.26 0.93 0.26
13584 BRD-K12184916 VCAP 0.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90612 BRD-K12184916 HCT116 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90657 BRD-K12184916 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.36
92047 BRD-K12184916 BT20 10 uM 3 h 0.0 0.0 0.0 -0.32 -1.08 0.81
92145 BRD-K12184916 HS578T 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92319 BRD-K12184916 MDAMB231 0.37 uM 3 h -0.2 -0.83 0.0 0.0 0.0 0.0
92395 BRD-K12184916 SKBR3 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
95428 BRD-K12184916 U2OS 10 uM 48 h 0.0 0.0 0.0 -0.38 -1.29 1.53
95971 BRD-K12184916 PHH 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
97311 BRD-K12184916 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97969 BRD-K12184916 P1A82 0.25 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
98793 BRD-K12184916 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99003 BRD-K12184916 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
116280 BRD-K12184916 A375 0.125 uM 24 h 0.22 0.94 0.05 -0.35 -1.18 1.14
120296 BRD-K12184916 A549 1.11 uM 24 h 0.26 1.07 0.2 -0.23 -0.77 0.08
120328 BRD-K12184916 HA1E 1.11 uM 24 h 0.29 1.2 0.43 -0.28 -0.95 0.41
120422 BRD-K12184916 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120501 BRD-K12184916 YAPC 3.33 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.01
128920 BRD-K12184916 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128962 BRD-K12184916 HT29 2.22 uM 24 h 0.26 1.08 0.22 -0.2 -0.68 0.02
128981 BRD-K12184916 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.72
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).