CMap Candidate Details

Structure:
CMap ID: C00062
Pert ID: BRD-A02333338
Compound Name: cyclopamine
Targets: SMO
MoA: Smoothened receptor antagonist
SMILES: CC1C2NC[C@@H](C)C[C@H]2O[C@@]31CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C
InchiKey: QASFUMOKHFSJGL-ACLNMQFHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29704 BRD-A02333338 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
29995 BRD-A02333338 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30278 BRD-A02333338 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
30609 BRD-A02333338 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30890 BRD-A02333338 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31186 BRD-A02333338 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31770 BRD-A02333338 HT29 10 uM 6 h 0.0 0.0 0.0 0.27 0.94 0.28
31955 BRD-A02333338 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32093 BRD-A02333338 NEU 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
32272 BRD-A02333338 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32691 BRD-A02333338 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
32867 BRD-A02333338 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33391 BRD-A02333338 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).