CMap Candidate Details

Structure:
CMap ID: C06208
Pert ID: BRD-K12244279
Compound Name: BRD-K12244279
Targets: --
MoA: --
SMILES: NC(Sc1ccc(N)cc1)=C(C#N)c1ccccc1C(F)(F)F
InchiKey: JLOXTZFYJNCPIS-FYWRMAATSA-N
Compound Aliases: MEK1-2-inhibitor

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1741 BRD-K12244279 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2084 BRD-K12244279 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2541 BRD-K12244279 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44857 BRD-K12244279 ASC 10 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
45430 BRD-K12244279 HT29 10 uM 6 h 0.22 0.93 0.04 0.41 1.47 2.24
45652 BRD-K12244279 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45972 BRD-K12244279 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46292 BRD-K12244279 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46607 BRD-K12244279 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97324 BRD-K12244279 HAP1 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97360 BRD-K12244279 A375 3.33 uM 24 h 0.2 0.81 0.0 0.0 0.0 0.0
100092 BRD-K12244279 U2OS 10 uM 6 h -0.19 -0.81 0.0 0.0 0.0 0.0
116010 BRD-K12244279 A549 10 uM 24 h -0.31 -1.28 0.77 0.26 0.92 0.25
116136 BRD-K12244279 HEPG2 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116260 BRD-K12244279 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).