CMap Candidate Details

Structure:
CMap ID: C06243
Pert ID: BRD-K12357156
Compound Name: AG-490
Targets: JAK2; JAK3
MoA: JAK inhibitor; EGFR inhibitor; ErbB2 inhibitor
SMILES: Oc1ccc(C=C(C#N)C(=O)NCc2ccccc2)cc1O
InchiKey: TUCIOBMMDDOEMM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4062 BRD-K12357156 HA1E 10 uM 24 h 0.25 1.03 0.13 0.0 0.0 0.0
4365 BRD-K12357156 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
4776 BRD-K12357156 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5035 BRD-K12357156 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.22 1.25
44305 BRD-K12357156 A375 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.86 0.22
44858 BRD-K12357156 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45163 BRD-K12357156 HEPG2 10 uM 6 h -0.24 -1.01 0.17 0.0 0.0 0.0
45431 BRD-K12357156 HT29 10 uM 6 h -0.32 -1.32 0.83 -0.35 -1.18 1.14
45773 BRD-K12357156 MCF??7.00 10 uM 6 h 0.21 0.9 0.02 0.0 0.0 0.0
45973 BRD-K12357156 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46293 BRD-K12357156 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46608 BRD-K12357156 SKB 10 uM 24 h 0.18 0.73 0.0 0.0 0.0 0.0
100094 BRD-K12357156 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).