CMap Candidate Details

Structure:
CMap ID: C06296
Pert ID: BRD-K12516989
Compound Name: zaprinast
Targets: PDE5A
MoA: Phosphodiesterase inhibitor
SMILES: CCCOc1ccccc1c2nc3nn[nH]c3c(=O)[nH]2
InchiKey: KFMVHONQQFRNNH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1550 BRD-K12516989 HA1E 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
1889 BRD-K12516989 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2160 BRD-K12516989 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2460 BRD-K12516989 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41728 BRD-K12516989 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41913 BRD-K12516989 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42301 BRD-K12516989 ASC 10 uM 24 h -0.23 -0.97 0.11 0.24 0.86 0.16
42634 BRD-K12516989 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42937 BRD-K12516989 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43160 BRD-K12516989 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43493 BRD-K12516989 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43796 BRD-K12516989 PHH 10 uM 24 h 0.28 1.17 0.36 -0.3 -1.01 0.56
44073 BRD-K12516989 SKB 10 uM 24 h -0.19 -0.8 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).