CMap Candidate Details

Structure:
CMap ID: C06360
Pert ID: BRD-K12735121
Compound Name: TG-100801
Targets: FGFR1; FLT1; KDR; SRC
MoA: Src inhibitor; VEGFR inhibitor
SMILES: Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1cc(OC(=O)c2ccccc2)ccc1Cl
InchiKey: JMGXJHWTVBGOKG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122239 BRD-K12735121 A375 10 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.06
122282 BRD-K12735121 A549 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
122311 BRD-K12735121 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122352 BRD-K12735121 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
122383 BRD-K12735121 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122408 BRD-K12735121 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122432 BRD-K12735121 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122462 BRD-K12735121 THP1 10 uM 24 h 0.29 1.21 0.45 0.0 0.0 0.0
122510 BRD-K12735121 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.72
130583 BRD-K12735121 HA1E 2.22 uM 24 h 0.21 0.89 0.02 -0.29 -0.97 0.45
130655 BRD-K12735121 HELA 0.08 uM 24 h 0.27 1.12 0.26 0.0 0.0 0.0
130696 BRD-K12735121 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).