CMap Candidate Details

Structure:
CMap ID: C06372
Pert ID: BRD-K12762134
Compound Name: XAV-939
Targets: TNKS2
MoA: Tankyrase inhibitor
SMILES: Oc1nc(nc2CCSCc12)-c1ccc(cc1)C(F)(F)F
InchiKey: KLGQSVMIPOVQAX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8913 BRD-K12762134 A375 12 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
9366 BRD-K12762134 AGS 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9919 BRD-K12762134 HA1E 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10165 BRD-K12762134 HCC515 12 uM 24 h -0.25 -1.04 0.22 0.0 0.0 0.0
10737 BRD-K12762134 HEPG2 12 uM 6 h 0.33 1.38 0.97 -0.26 -0.87 0.23
10947 BRD-K12762134 HT29 12 uM 24 h 0.21 0.88 0.01 -0.28 -0.93 0.35
11172 BRD-K12762134 MCF??7.00 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11425 BRD-K12762134 NCIH2073 12 uM 6 h -0.23 -0.95 0.09 0.31 1.08 0.66
11716 BRD-K12762134 NCIH508 12 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.55
12737 BRD-K12762134 SW480 12 uM 6 h 0.0 0.0 0.0 -0.31 -1.05 0.7
13216 BRD-K12762134 U937 12 uM 6 h 0.26 1.09 0.22 -0.23 -0.77 0.08
13585 BRD-K12762134 VCAP 12 uM 6 h 0.0 0.0 0.0 0.27 0.95 0.31
90554 BRD-K12762134 A549 1.25 uM 24 h 0.23 0.98 0.09 0.24 0.86 0.16
96784 BRD-K12762134 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.33 -1.12 0.95
98212 BRD-K12762134 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
98341 BRD-K12762134 NEU 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).